Paul D. Lyons, MD, Ph.D.

Founder and Director of the Virginia Comprehensive Epilepsy and Neurodevelopmental Clinic




Epilepsy and Neurodevelopmental Clinic

Sleep Disorders Clinic

Clinical Research Studies/Clinical Interests:
Epilepsy Surgery
Neuropsychological, Psychiatric, and Behavioral Consequences of Epilepsy
Novel Class of Molecules Research for treatment of pharmacologically refractory epilepsy.
Biomedical devices
Sleep disturbances

Education and Training:
Doctor of Medicine, University of Alabama at Birmingham, School of Medicine
Doctorate of Philosophy, University of Alabama, Birmingham, Department of Physiology and Biophysics.
Internship:  University of Alabama at Birmingham Hospital, School of Medicine, Department of Internal Medicine
Residency:  University of Virginia, Department of Neurology, School of Medicine

Epilepsy and Neurophysiology, University of Virginia, Department of Neurology, Division of Epilepsy and Neurophysiology, School of Medicine
University of Alabama at Birmingham, Department of Cell Biology, Research Fellowship.

Board Certifications:
American Board of Psychiatry and Neurology
Board Certified in Neurology
Board Certified in Sleep Medicine
Board Certified in Clinical Neurophysiology
Board Certified in Epilepsy

State Licensures:

Licensed Physician, State of Virginia

Licensed Physician, State of Washington

Licensed Physician, State of New York

Professional Committees/Society Memberships:
International Society for Neurofeedback and Research
Institute of Electrical and Electronics Engineers
Society of Nuclear and Molecular Medicine
Applied Psychophysiology and Biofeedback
American Epilepsy Society
American Academy of Sleep Medicine
Epilepsy Foundation of Virginia, Professional Advisory Board
National Association of Epilepsy Centers


  • Lyons PD, Bodamer MF, Lyons EJ, Harry LP, Effective ‘Seizure Detection Device’ In Refractory-Symptomatic Localization Related Epilepsy: A Case Report (2.299) AES, Washington DC 12/2013
  • Lyons PD, Selznick L Characteristics of Intractibility in a Community-based Epilepsy Surgery Program. Poster, AES, San Antonio, TX 12/2010.
  • Calkins ME, Tepper P, Ruben Gur RC, Daniel Ragland, Go RCP, Klei L ,Savage RM, O’Jile J, Devlin B, Kwentus J , Aliyu MH, Allen T, Bradford LD, Edwards N, Lyons PD, Nimgaonkar VL, Santos AB, & Gur RE Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS):Evidence for Impairment and Heritability of Neurocognitive Functioning in Families of Schizophrenia Patients. Am J Psychiatry, 167(4): 459-472, 2010.
  • Linkage analysis of schizophrenia in African-American families. Schizophr Res.<> 2009 Apr;109(1-3):70-9.
  • MH Aliyu, Calkins ME, Swanson CL Jr, Lyons PD, Savage RM, May R, Wiener H, McLeod-Bryant S, Nimgaonkar VL, Ragland JD, Gur RE, Gur RC, Bradford LD, Edwards N, Kwentus J, McEvoy JP, Santos AB, McCleod-Bryant S, Tennison C, Go RC, Allen TB; PAARTNERS Study Group.<> Project among African-Americans to explore risks for schizophrenia (PAARTNERS): recruitment and assessment methods. Schizophr Res. Oct;87 (1-3):32-44, 2006
  • Hamilton LA, Aliyu MH, Lyons PD, May R, Swanson CL, Savage R, Go RCP. African American community attitudes and perceptions toward schizophrenia and medical research: an exploratory study, JNMA, 98(1): 18-27, 2006
  • Lyons, PD and Benveniste, EN Cleavage of Membrane-associated ICAM-1 from astrocytes: involvement of a metalloprotease, Glia, 22(2): 103-112, 1998.
  • Lyons, PD and Blalock, JE Pro-opiomelanocortin gene expression and protein processing in rat mononuclear leukocytes., J. of Neuroimmunology, 78: 47-56, 1997.
  • Lyons, PD and Blalock, JE The kinetics of ACTH expression in rat leukocyte subpopulations., J. of Neuroimmunology, 63: 103-112, 1995.